A Liquid crystal creams represent a novel approach in skincare formulations, leveraging the unique properties of liquid crystal technology to improve skin hydration and barrier function. The composition, structure, and skincare benefits of recent developments in liquid crystal cream formulations are highlighted in this article. Liquid crystal creams mimic the lipid bilayers of the skin, offering enhanced compatibility and permeability. Liquid crystal creams have emerged as a promising vehicle for topical drug delivery in pharmaceutical formulations, offering unique advantages for enhancing drug permeation, stability, and efficacy. This comprehensive review explores the application of liquid crystal technology in topical drugdeliverysystems, witha focus on composition, structure, and therapeutic applications. Liquid crystal creams, by mimicking the organization of biological membranes, facilitate the penetration of drugs across the skin barrier, resulting in improved bioavailability and therapeutic outcomes. Their versatile composition allows for the incorporation of à wide range of drugs, including hydrophilic and lipophilic compound, peptides, and proteins, enabling targeted delivery to specific skin layers or underlying tissues. Furthermore, the rheological properties of liquid crystal creams can be tailored to optimize drug release kinetics, providing sustained and controlled drug delivery over extended periods. Additionally, the incorporation of penetration enhancers and other excipients into liquid crystal creams can further enhance drug permeation and tissue targeting, expanding their potential applications in dermatology, cosmeceuticals, and wound healing. This review highlights the potential of liquid crystal creams as versatile and effective platforms for topical drug delivery in pharmaceutical formulations, with opportunities for continued research and development to optimize their performance and clinical utility.