Welcome to Indo American Journal of Pharmaceutical Research

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Anitha K*1, T. M. Kalyankar2, U. A. Khedkar2, R. B. Gholve2
1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram - 515003, Andhra Pradesh, India.

2School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded - 431606, Maharashtra, India.

Graphical Abstract

Abstract Article Highlights Download PDF (57) Google Scholar

SIMULTANEOUS DETERMINATION OF METFORMIN AND GLIBENCLAMIDE IN PHARMACEUTICAL PREPARATION BY RP-HPLC

Anitha K¹, T. M. Kalyankar², V. B. Ingale² and Ashok P Gingine³

¹Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram-515003, Andhra Pradesh, India.

²School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

³School of Educational Sciences, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

Graphical Abstract

Abstract Article Highlights Download PDF (47) Zenodo DOI Google Scholar

DOI Link

A VALIDATED RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ARTESUNATE, SULFADOXINE AND PYRIMETHAMINE IN BULK AND TABLETS FORMULATION

Anitha K¹, T. M. Kalyankar², Khan Jawad S. A.² and Ashok P Gingine³
¹Department of Chemistry, Sri Krishnadevaraya University, Ananthapuram-515003, Andhra Pradesh, India.
²School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.
³School of Educational Sciences, Swami Ramanand Teerth Marathwada University, Nanded (431 606), MS India.

Graphical Abstract

Abstract Article Highlights Download PDF (41) Zenodo DOI Google Scholar

DOI Link

A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Dr Sally John^1*,Dr.Amrita Singam², Dr Sonia Mary Thomas³
¹Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Sawangi ,Wardha, Maharashtra Pin 442 001.
²Indira Gandhi Govt. Medical College, Department.of Pharmacology, Nagpur.
³Santhula Trust Hospital, Vadakkara, Oliyapuram P.O Kuthattukulam, Ernakulam Dt, Kerala.

Graphical Abstract

Abstract

Liaison psychiatry specializes in bridging psychiatric services to other specialities. It has been actively intervening in the reduction of the communication gap between the various specialities in many health care setups. Thereby it provides them the ability to acquire adequate understanding about the intricacies involved in treating patients with physical and psychiatric co-morbidities. Efficient communication between different levels of care has a great impact on quality of health care. Objectives: To assess the source of referral, reason for referral, the psychiatric diagnosis of the patients referred and the Psychiatric treatment initiated by the referring team and the knowledge of the illness. Materials and method: The study was a cross sectional study conducted on the out patients and inpatients referred to the psychiatric department in a tertiary care hospital in central India. It was completed in the time period of 3 months from June 1st 2014 to August 15th 2014 with a sample size of 150 patients. All the referred patients were evaluated by a consultant psychiatrist and diagnosis was made according to the diagnostic guidelines of ICD-10 (International Classification of Diseases -10th Edition). Results: Out of the total number of patients who were referred 79(52.6%) patients were males and 71(47.3%) were females. The mean age of the study population was 36.01 years. A majority of the patients belonged to the age group of 21-30 years. A majority of the referrals were made from the department of medicine (n=76, 50.6%).The various reasons for psychiatric referral were analyzed and it was found that the most common reason was the presence abnormal behaviour (n=37, 24.6%). The most common psychiatric diagnosis made was substance use disorders (n=51, 34%) Conclusion: The observations of our study clearly show that there is significant gap existing in consultation liaison psychiatry as reflected in the profile and patterns referrals assessed. Early diagnosis and management of psychiatric disorders in patients presenting to the other departments with various physical illnesses definitely hasten recovery, reduce morbidity and improve quality of life. The way ahead is too long in this field and the need for improving the liaison is crucial in reducing the burden of morbidity and improving the quality of life of the patient and their carers.

Article Highlights Download PDF (8) Google Scholar

FORMULATION DEVELOPMENT AND EVALUATION OF ORODISPERSIBLE TABLETS OF VALSARTAN USING SPRAY DRIED DILUENTS

MahaleNitin B^*1, Battase A.P².
¹Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
²GovindraoNikam College of Pharmacy, Sawarde, Tal ChiplunDistRatnagiri, (M.S), India.

Graphical Abstract

Abstract Article Highlights Download PDF (15) Google Scholar

FORMULATION DEVELOPMENT AND EVALUATION OF NOVEL ORODISPERSIBLE TABLETS OF OLMESARTAN

Mahale Nitin B^*1, Battase A.P².
¹Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, India.
²GovindraoNikam College of Pharmacy, Sawarde, Tal ChiplunDistRatnagiri, (M.S), India.

Graphical Abstract

Abstract Article Highlights Download PDF (18) Google Scholar

A REVIEW ON NOVEL DRUG DELIVERY SYSTEMS ON LINCOSAMIDE ANTIBIOTICS-CLINDAMYCIN A MODEL DRUG

Ms. Shrestha, Mrs .T. Chakraborty^*, Mrs. Aisha Khanum

Al-Ameen College of Pharmacy, Hosur Road, Opposite Lalbagh Main Gate, Bangalore-560027.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

PRE-FORMULATION STUDIES FOR FORMULATION AND DEVELOPMENT OF ETHOSOMAL GEL OF OXICONAZOLE NITRATE

Wasim Ahmed Khan^*1, Dr. Pushpendra Kannojia², Rahul Sen³, Rohit Kumar Bijauliya², Varsha Yadav⁴

¹Modern College of Pharmacy, Jhansi, Uttar Pradesh, India.

²BIU College of Pharmacy, Bareilly International University, Bareilly, Uttar Pradesh, India.

³Bhagwan Singh Institute of Pharmacy, Ajanari, Orai, Uttar Pradesh, India.

⁴Institute of Pharmacy, Bundelkhand University Jhansi, Uttar Pradesh, India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

ASSESSMENT OF ADHERENCE TO INHALERS IN COPD PATIENTS

Gikku Mariyam Varghese^1*, Deepa Koshy², Dr.Josna James³, Dr.Abel Abraham Thomas⁴

^1,2Nazareth College of Pharmacy, Othera, Thiruvalla.

³Believers Church Medical College, Thiruvalla.

⁴Department of Pharmacy Practice, Nazareth College of Pharmacy, Othera, Thiruvalla.

Graphical Abstract

Abstract

BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are of significant concern worldwide owing to their high prevalence and substantial clinical and economic burden. Adherence to inhaler may be evaluated by the speci?c inhaler adherence questionnaire, the Test of Adherence to Inhalers (TAI). OBJECTIVE: To assess the adherence profiles to inhaled therapies in COPD patients. SETTING: A 500 bedded tertiary care hospital in South India. METHOD: A prospective observational study was carried out in a tertiary care hospital in South India with a sample size of 150. MAIN OUTCOME MEASURE: To evaluate the adherence to inhalers in COPD patients and thereby taking measures to improve their adherence. RESULT: Among the study population 66% were males. The majority of patients (41.33%) were in the age group of 61-70 years. The present study shows that COPD was prevalent more in males than females. The elderly patients were at high risk of developing COPD. The non-adherence to inhalers were was associated with busy schedule, financial constraints and mood changes. CONCLUSION: Several factors may predict the incorrect use of inhalers or adherence in COPD outpatient, including the number of devices and the daily dosing frequency. Ideally, patient education, simplicity of the device operation, the use of just one device for multiple medications and the best adaptation of the patient to the inhaler should guide the physician in prescribing the device.BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are of significant concern worldwide owing to their high prevalence and substantial clinical and economic burden. Adherence to inhaler may be evaluated by the speci?c inhaler adherence questionnaire, the Test of Adherence to Inhalers (TAI). OBJECTIVE: To assess the adherence profiles to inhaled therapies in COPD patients. SETTING: A 500 bedded tertiary care hospital in South India. METHOD: A prospective observational study was carried out in a tertiary care hospital in South India with a sample size of 150. MAIN OUTCOME MEASURE: To evaluate the adherence to inhalers in COPD patients and thereby taking measures to improve their adherence. RESULT: Among the study population 66% were males. The majority of patients (41.33%) were in the age group of 61-70 years. The present study shows that COPD was prevalent more in males than females. The elderly patients were at high risk of developing COPD. The non-adherence to inhalers were was associated with busy schedule, financial constraints and mood changes. CONCLUSION: Several factors may predict the incorrect use of inhalers or adherence in COPD outpatient, including the number of devices and the daily dosing frequency. Ideally, patient education, simplicity of the device operation, the use of just one device for multiple medications and the best adaptation of the patient to the inhaler should guide the physician in prescribing the device.

Article Highlights Download PDF (48) Zenodo DOI Google Scholar

DOI Link

DRUG UTILIZATION EVALUATION OF POST-OPERATIVE ANTIMICROBIALS USED IN SURGERY DEPARTMENT OF A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Deepa Koshy^1*, Abiya Susan Shibu¹, Sanisha V Soman¹, Mahima Jose¹, Mrs. Nisha Pothen²

¹6^th year Pharm D Students, Nazareth College Of Pharmacy, Othera, Thiruvalla.

²Assistant Professor, Department Of Pharmacology, Nazareth College Of Pharmacy, Othera, Thiruvalla.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

GOLD NANOPRATICLES IN SCIENCE, TECHNOLOGY AND HEALTH CARE: A REVIEW

Gaurav M. Prajapati^*, Dipak B. Khillare^*, Komal E. Palaskar,Ayesha I. Shaikh, Jayshri S. Gadhave

Kasturi Shikshan Sanstha’s College of Pharmacy, Pune, Maharashtra, India.

Graphical Abstract

Abstract

The gold colloid is a solution of colloidal nanoparticles in gold in its liquid state. These particles are usually red in color. Due to their versatile properties in the field of optics, electronics, and molecular recognition, they are subjected to immense research. They are a preferred choice in technologies like electron microscopy, electronics, nanotechnology, material sciences, and health care. In many different types of colloidal gold synthesis, the combination of gold nanoparticles with certain ligands can increase its potent and usage in different fields. They are capable of delivering useful drugs in difficult areas like the brain, retina, tumors, and intracellular organelles. However, their efficiency highly depends on their size and shape. They are also under study as carriers for serious drugs like Paclitaxel. Gold nanoparticles are also used in drugs used for the treatment of cancer. However, if consumed in unprescribed amounts have proved to be toxic to the body. Different sizes of gold particles have shown buildup in parts of the brain, stomach, pancreas, kidneys, liver and blood. Gold nanorods have shown properties for being used as photothermal agents in vivo applications. Gold nanoparticles are modified into nanorods, nanoshells, nanocages, etc. Gold nanoparticles are also used in on-site detection of harmful gases like H₂S.The gold colloid is a solution of colloidal nanoparticles in gold in its liquid state. These particles are usually red in color. Due to their versatile properties in the field of optics, electronics, and molecular recognition, they are subjected to immense research. They are a preferred choice in technologies like electron microscopy, electronics, nanotechnology, material sciences, and health care. In many different types of colloidal gold synthesis, the combination of gold nanoparticles with certain ligands can increase its potent and usage in different fields. They are capable of delivering useful drugs in difficult areas like the brain, retina, tumors, and intracellular organelles. However, their efficiency highly depends on their size and shape. They are also under study as carriers for serious drugs like Paclitaxel. Gold nanoparticles are also used in drugs used for the treatment of cancer. However, if consumed in unprescribed amounts have proved to be toxic to the body. Different sizes of gold particles have shown buildup in parts of the brain, stomach, pancreas, kidneys, liver and blood. Gold nanorods have shown properties for being used as photothermal agents in vivo applications. Gold nanoparticles are modified into nanorods, nanoshells, nanocages, etc. Gold nanoparticles are also used in on-site detection of harmful gases like H₂S.

Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

ADVANCE TECHNIQUES IN TREATING CUTANEOUS FUNGAL INFECTIONS.

Mr. Siddu K Mavintop, Mrs. Aisha Khanum, Ms. Ayesha Syed

Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore -560027 India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

REVIEW ON CELLULOSE DERIVATIVES

Mr. Paresh A. Patil^1*, Mr. Lilachand B. Patil^2*, Mr. Mayur S. Patel^3*,Mr. Swapnil D. Deo^4*.

¹Ahinsa Institute of Pharmacy, Dondaicha,Shindkheda,Dhule.(MS) 425408 [India].

²K D Gavit Diploma In Pharmacy College, Pathrai, Nandurbar.(MS).

³NTVS's College of Pharmacy, Nandurbar.(MS).

⁴TSPM’s Trimurti Institute of Pharmacy, Paldhi, Jalgaon.(MS).

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

PHARMACOGNOSTIC AND PHYTO-PHARMACOTHERPEUTIC PROFILE OF SPHAERANTHUS INDICUS: A POTENT INDIAN FOLK LORE MEDICINAL PLANT

Rakesh P. Prajapati^1*, Manisha V. Kalariya², Naishadh Solanki¹, Ghanshyam Sanghani¹, Vineet Jain¹

¹Bhagwan Mahavir College of Pharmacy, GTU, Surat, Gujarat, India.

²BK Mody Govt. Pharmacy College, GTU, Rajkot, Gujarat, India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NEW 2-AMINO PYRIMIDINE DERIVATIVES

Dr.Siddharth Desai, Anand S.N., Dr. Kishore Singh C., Dr. Ashok Malpani.

Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Balaji Nagar, Jewargi Old Road, Kalaburagi-585102, Karnataka, India.

Graphical Abstract

Abstract

2-substituted derivativesof indane-1,3-diones have shown many activities. Chalcones possess a number of biological and pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, anticancer, anti-tubercular, and antioxidant activities etc. The synthesis of chalcone compounds incorporating with heterocycles became great importance in medicinal chemistry. Literature survey revealed that Chalcones and Pyrimidine derivatives possess a broad spectrum of biological activities like antimicrobial, anti-inflammatory, antimalarial, antitubercular, anticancer, antidepressant and antamoebic etc.Hence an attempt is made to synthesize some new chalcones from 2- acetyl-indane- 1,3- dione with various substituted aromatic/ heteroaromatic aldehydes by the Claisen Schmidt condensation. The resulted chalcones have been converted into their 2-amino pyrimidine derivatives by reaction with guanidine hydrochloride. The resulted compounds were identified by physical and spectral methods and were also screened for their antibacterial and antifungal activities based on the reported literature. 2-substituted derivativesof indane-1,3-diones have shown many activities. Chalcones possess a number of biological and pharmacological activities such as antibacterial, antifungal, antimalarial, anti-inflammatory, anticancer, anti-tubercular, and antioxidant activities etc. The synthesis of chalcone compounds incorporating with heterocycles became great importance in medicinal chemistry. Literature survey revealed that Chalcones and Pyrimidine derivatives possess a broad spectrum of biological activities like antimicrobial, anti-inflammatory, antimalarial, antitubercular, anticancer, antidepressant and antamoebic etc.Hence an attempt is made to synthesize some new chalcones from 2- acetyl-indane- 1,3- dione with various substituted aromatic/ heteroaromatic aldehydes by the Claisen Schmidt condensation. The resulted chalcones have been converted into their 2-amino pyrimidine derivatives by reaction with guanidine hydrochloride. The resulted compounds were identified by physical and spectral methods and were also screened for their antibacterial and antifungal activities based on the reported literature.

Article Highlights Download PDF (48) Zenodo DOI Google Scholar

DOI Link

RECENT ADVANCES IN MICROWAVE- ASSISTED SYNTHESIS

Renuka Jawale^*, Sangram U. Deshmukh, Nandkishor B. Bavage, Vidyasagar Gali, Shyamlila B. Bavage

Latur College of Pharmacy Hasegaon, Tq. Ausa, Dist. Latur- 413512, Maharashtra, India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

PROSPECTIVE ASSESSMENT OF CHRONIC HEPATITIS B INFECTION AND CHRONIC HEPATITIS C INFECTION AS A RISK FACTOR IN ANTI-TUBERCULAR DRUGS INDUCED LIVER INJURY PATIENTS IN A TERTIARY HEALTH CARE HOSPITAL AT DEHRADUN, UTTARAKHAND (INDIA)

Rohit Bangwal, Jagdish Rawat, Dev Singh Jangpani

Department of Pharmacy Practice, School of Pharmaceutical Science, Shri Guru Ram Rai University, Patel Nagar, Dehradun-248001, Uttrakhand, India.

Graphical Abstract

Abstract

Background: Anti-tubercular drug-induced liver injury (ATDILI) is a major safety concern for the treatment of tuberculosis (TB). The impact of chronic hepatitis B infection (CHBI) and chronic hepatitis C infection (CHCI) on the risk of ATDILI is still controversial. In this study, we aimed to assess systematically the influence of CHBI, CHCI on the susceptibility to ATDILI patients. Aims and objectives: To study of the Chronic Hepatitis B infection and Chronic Hepatitis C infection as a risk factor in anti-tubercular drug-induced liver injury: A Prospective observational study. Materials and method: Prospectively, we identified 24 cases of ATDILI among 172 patients diagnosed with confirmed pulmonary tuberculosis between July 2018 to December 2018. None of the patients with established risk factor as ATDILI as recognized by ATS guidelines was included in our study population. Regular clinical and liver function test monitoring was done at the commencement of ATT. Results: Among these, 02 (8.3%) patients had hepatitis B virus (HBV) and 02 (8.3%) patients had hepatitis C virus (HCV), out of 24 ATDILI patients. Among the ATDILI cases, 03 patients had grade-1 DILI, 06 patients had grade-2 DILI, and 14 patients had grade-3 DILI, and 01 patients had grade-4 of the DILI cases fulfilled the ATS/BTS criteria for TB DILI. There were no human immunodeficiency virus (HIV) co-infected patients. Among the total 24 patients are developed the ATT induce hepatotoxicity. Among the total 24 patients anti tubercular drug induce hepatotoxicity cases, female patients 14 (8.13%) account for the highest number of risks ATDILI. Conclusion: This study suggests that CHBI, CHCI may increase the risk of ATDILI in the standard combination therapy for active TB. In patients of pulmonary tuberculosis drug induced hepatitis is common. However viral marker should be considered to rule out hepatitis B and hepatitis C. Close follow-up and regular liver test monitoring, viral marker is mandatory to treat TB in chronic hepatitis B and C carriers. DILI is a common problem among patients on ATT in our population. Early detection not only reduces the risk of developing Hepatic Failure but also prevents mortality rate.

Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

KNOWLEDGE, ATTITUDE AND PRACTICE ASSESSMENT OF SOUTH SUDANESE REFUGEES IN ETHIOPIA TOWARDS TRADITIONAL MEDICINE: A CROSS SECTIONAL STUDY

Francis Majok¹, Gemmechu Hasen^{1, 2*}

¹Jimma University, Jimma, Oromia, Ethiopia.

²Jimma University Laboratory of Drug Quality (JuLaDQ), Jimma University, Jimma, Ethiopia.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

KNOWLEDGE, ATTITUDE AND PRACTICE ASSESSMENT OF DRUG DISPENSERS TOWARDS DRUG PRODUCTS STABILITY AT DRUG OUTLETS IN JIMMA TOWN: A CROSSECTIONAL STUDY

Gemmechu Hasen^{1, 2*}, Hawi Hussen⁴, Fuad Abduro³, Sileshi Below^{1, 2} Mohammed Aliyi¹

¹School of Pharmacy, Faculty of Health Sciences, Jimma University, Jimma, Oromia, Ethiopia.

^1,2Jimma University Laboratory of Drug Quality (JuLaDQ), Jimma University, Jimma, Ethiopia.

³Department of Chemistry, College of Natural Science, Jimma University, P.O. box 378, Jimma, Ethiopia.

⁴Department of Environmental Health, Faculty of Health Sciences, Jimma University, Jimma, Oromia, Ethiopia.

Graphical Abstract

Abstract

Background: Aspects of drug product stability are of primary concern to dispensers in the dispensing of drugs at drug retail outlet. Therefore, this study assessed knowledge, attitude and practice of drug dispensers towards drug product stability at community pharmacies in Jimma town. Method: Cross-sectional study was conducted on total of 19 dispensers from Jimma private drug outlet (n=19) in Jimma town from January to June 2019. Data on knowledge, attitude, practice of dispensers towards drug stability, and sociodemographic characteristics of respondents were collected using a structured interviewer administered questionnaire. Data was analyzed by using SPSS Version 21.0 (Chicago, SPSS Inc.). The Chi square test was used to determine association between practice of maintaining drug stability through proper storage condition among respondents and sociodemographic characteristics of dispensers. Results: A total of 19 dispensers were included in this study, 13(68.4%) of the dispensers was males and mean age was 47±13 years. Thirteen (68.4%) were pharmacists and 5(26.3%) were pharmacy technicians (druggists). Twelve (63.2%) of drug dispensers revealed stability of drugs product as critical element in pharmaceutical regulatory system. Majority of respondents (36.8%) stated that stability of drug products were affected during storage condition. Moreover, study revealed that years of dispensing experience (p=0.007) and educational qualification (p=0.001) of dispensers were significantly associated with practice of maintaining drug stability through proper storage condition. Conclusions: Study revealed that majority of dispensers has a good knowledge and attitude towards drug stability at drug retail outlet of Jimma town. Moreover, years of dispensing experience and educational qualification of dispensers were significantly associated with practice of maintaining drug stability through proper storage condition. Compliance of drug retail outlet to regulatory standard assessment is paramount important.

Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

SYNTHESIS AND CHARACTERIZATION OF ISOMERS OF COX-2 INHIBITOR, CELECOXIB

Rajesh Reddy P^1,2,^*Sivanadh Musunuri,Rama Sekhara Reddy D²,V Subrahmanyam Chittala²,VNS Murthy P²,Krishnamohan K¹

¹Monvi Labs, 3rd floor, Plot No 97, Rd Number 9, ALEAP Industrial Area, Gajularamaram, Hyderabad, Telangana 500090, India.

²Department of Chemistry, Krishna University, Machilipatnam – 521001, Andhra Pradesh, India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

DESIGN & MOLECULAR DOCKING STUDIES OF COUMARIN SUBSTITUTED 1, 3, 4-OXADIAZOLES AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS.

Purohit S.S.^*, Kulkarni V.H., Joshi S.D.

S.E.T.’s College of Pharmacy, S. R. Nagar, Near Microwave Tower, Dharwad-580002.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

DECOMPRESSIVE CRANIECTOMY WITH EVACUATION OF BLOOD IN HYPERTENSIVE BLOOD SURGICAL OUTCOME

Dr Jahanzeb Kakar, Dr. Nusrullah Lango, Dr. Asghar Baber, Prof. Naqibuallah Achakzai, Dr. Ibrahim Sheikh, Dr. Irfan Adil, Mir Zaman Kasi

Bolan Medical College Quetta, Balochistan Pakistan.

Graphical Abstract

Abstract Article Highlights Download PDF (89) Zenodo DOI Google Scholar

DOI Link

STUDY TO COMBAT ANTIBIOTIC RESISTANCE WITH STEWARDSHIP PROGRAM

Faaria Siddiqui^*1, M. Crystal Nissy¹, Ruba Sana¹, Dr. Anupama Koneru¹, Ms. Khwaja Amtul Raouf Qazi¹, Dr. Uma Sreedevi²
¹Department of Pharmacy Practice, Sultan-Ul-Uloom College of Pharmacy, Hyderabad, Telangana, India.
²Aster Prime Hospital, Hyderabad, Telangana, India.

Graphical Abstract

Abstract

Background: The global antimicrobial resistance burden is growing and is associated with increased morbidity and mortality in both clinical and community settings. The spread of antibiotic resistance to different environmental niches and the emergence of superbugs complicate the control strategies even further. International, national, and local approaches to antimicrobial resistance management and prevention have been suggested. To combat antimicrobial resistance, a multidisciplinary, collaborative, regulatory approach is needed. Aim: The aim of this study is to highlight the use of antimicrobial stewardship which helps us achieve optimal outcome of the infection with minimizing toxicity, reducing costs and limiting microbial resistance throughout the rational use of antibiotics. Stewardship strategies are discussed, and a strategy is developed for implementing a stewardship program. Objectives:To assess the Prescription pattern in infectious diseases. To monitor the clinical outcomes in patients treated with different antimicrobial therapies in infectious diseases. To analyse the antibiotic sensitivity pattern of common microorganisms. Evaluation of the rational and irrational use of drugs. De-escalation of antimicrobial therapy (stewardship program) Methods: This is a prospective observational study that was conducted to assess antibiotic therapy and its clinical outcomes in infectious diseases over a period of six months using designed data collection form as a tool. Results: Of the 150 patients analysed over a period of six months, it was observed that, for the antibiotics prescribed by the hospital physicians, only 43% of antibiotics were observed to be rational while 57% were irrational. Conclusion: Our results show that the choices of antibiotics only occasionally comply with the ICMR and NCDC guidelines for the management of infectious patients. We therefore concluded that irrationality in prescribing was more prominent and therefore implementation of Antibiotic Stewardship Program is essential.

Article Highlights Download PDF (41) Zenodo DOI Google Scholar

DOI Link

REVIEW ON: PHARMACEUTICAL DRUG REGULATORY AFFAIRS & REGULATORY REQUIREMENT FOR DRUGS APPROVAL IN INDIA, US & EUROPE MARKET

Suthar Narayan*, Agarwal Gourav
Ocean College/Ocean Edu Academy, Anadara Choraha (Circle), Rampura Road, Sirohi (307001).

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

NEUROPSYCHOLOGICAL STUDY ON ALZHEIMERS DISEASE : AN OVERVIEW OF PATHOGENESIS AND DIFFERENT TREATMENT APPROACHES

AHMED M^*, SANA. SS, HAFIZA BS, SABA MK

Dept. of Pharmacy Practice, Shadan College of Pharmacy.

Graphical Abstract

Abstract Article Highlights Download PDF (34) Zenodo DOI Google Scholar

DOI Link

DRUG UTILIZATION PATTERN OF ANTI DIABETIC DRUGS IN TYPE II DIABETIC PATIENTS IN A TEACHING AND GENERAL HOSPITAL

Mohamed Ahmed, Sheema Baqtiyar, Ruqiya Khanum, Kulsum Fatima, Anees Fatima

Dept.of Pharmacy Practice, Shadan College of Pharmacy, Peerancheru, Hyderabad.

Graphical Abstract

Abstract

BACKGROUND: Diabetes mellitus is defined as abnormal increase in levels of sugar (glucose) in the blood. Diabetes is a chronic (long-lasting) disease that affects how your body turns food into energy. In people with diabetes, blood sugar levels remain high. This may be because insulin is not being produced at all or is not made at sufficient levels, or is not as effective as it should be. The most common forms of diabetes are type 1diabetes (5%), which is an autoimmune disorder, and type 2 diabetes (95%), which is associated with obesity. Gestational diabetes is a form of diabetes that occurs in pregnancy, and other forms of diabetes are very rare and are caused by a single gene mutation. OBJECTIVE: The present study was undertaken to study the drug utilization pattern of anti-diabetic drugs in diabetic patients. METHOD: A six-month prospective observational study was carried out at Shadan teaching and general hospital, Peerancheru (Hyderabad). The data was collected from the case sheets of in patients and OPD cards of outpatients and critically analyzed using predetermined criteria. RESULTS: Out of 250 patients, 110(44%) patients were males and 140(56%) patients were females. It is observed that diabetes mellitus II is more common in patients of age groups (51-60) years. Pharmacotherapy revealed that 210 (81.6%) patients were treated with monotherapy followed by 34 (14%) patients with 2 drug therapy and 6 (4.4%) patients were prescribed with 3 drug therapy. Metformin was the drug of choice in monotherapy while metformin along with glimepiride was the preferred drug combination used in both 2 drug and 3 drug therapies. The overall drug usages in this study revealed that a total number of 301 drugs were prescribed. Out of which, metformin was most prescribed [128 (42.52%)]. CONCLUSION: Periodic evaluation of drug utilization patterns need to be done to provide suitable medications profile in prescription of drugs to increase the therapeutic benefit and reduce the adverse effects. The study of prescribing patterns require regular monitoring and evaluation and if necessary, suggestion of modification in prescribing pattern of medical practitioners to make medical care rational and cost effective. The current anti diabetic drugs includes insulin preparation and oral hypoglycemic agents (OHA), the preference is given mostly to metformin which is first choice of drug but the other drugs such as human insulin is also prescribed for many patients, also some combinations of (OHA) drugs are also preferred.BACKGROUND: Diabetes mellitus is defined as abnormal increase in levels of sugar (glucose) in the blood. Diabetes is a chronic (long-lasting) disease that affects how your body turns food into energy. In people with diabetes, blood sugar levels remain high. This may be because insulin is not being produced at all or is not made at sufficient levels, or is not as effective as it should be. The most common forms of diabetes are type 1diabetes (5%), which is an autoimmune disorder, and type 2 diabetes (95%), which is associated with obesity. Gestational diabetes is a form of diabetes that occurs in pregnancy, and other forms of diabetes are very rare and are caused by a single gene mutation. OBJECTIVE: The present study was undertaken to study the drug utilization pattern of anti-diabetic drugs in diabetic patients. METHOD: A six-month prospective observational study was carried out at Shadan teaching and general hospital, Peerancheru (Hyderabad). The data was collected from the case sheets of in patients and OPD cards of outpatients and critically analyzed using predetermined criteria. RESULTS: Out of 250 patients, 110(44%) patients were males and 140(56%) patients were females. It is observed that diabetes mellitus II is more common in patients of age groups (51-60) years. Pharmacotherapy revealed that 210 (81.6%) patients were treated with monotherapy followed by 34 (14%) patients with 2 drug therapy and 6 (4.4%) patients were prescribed with 3 drug therapy. Metformin was the drug of choice in monotherapy while metformin along with glimepiride was the preferred drug combination used in both 2 drug and 3 drug therapies. The overall drug usages in this study revealed that a total number of 301 drugs were prescribed. Out of which, metformin was most prescribed [128 (42.52%)]. CONCLUSION: Periodic evaluation of drug utilization patterns need to be done to provide suitable medications profile in prescription of drugs to increase the therapeutic benefit and reduce the adverse effects. The study of prescribing patterns require regular monitoring and evaluation and if necessary, suggestion of modification in prescribing pattern of medical practitioners to make medical care rational and cost effective. The current anti diabetic drugs includes insulin preparation and oral hypoglycemic agents (OHA), the preference is given mostly to metformin which is first choice of drug but the other drugs such as human insulin is also prescribed for many patients, also some combinations of (OHA) drugs are also preferred.BACKGROUND: Diabetes mellitus is defined as abnormal increase in levels of sugar (glucose) in the blood. Diabetes is a chronic (long-lasting) disease that affects how your body turns food into energy. In people with diabetes, blood sugar levels remain high. This may be because insulin is not being produced at all or is not made at sufficient levels, or is not as effective as it should be. The most common forms of diabetes are type 1diabetes (5%), which is an autoimmune disorder, and type 2 diabetes (95%), which is associated with obesity. Gestational diabetes is a form of diabetes that occurs in pregnancy, and other forms of diabetes are very rare and are caused by a single gene mutation. OBJECTIVE: The present study was undertaken to study the drug utilization pattern of anti-diabetic drugs in diabetic patients. METHOD: A six-month prospective observational study was carried out at Shadan teaching and general hospital, Peerancheru (Hyderabad). The data was collected from the case sheets of in patients and OPD cards of outpatients and critically analyzed using predetermined criteria. RESULTS: Out of 250 patients, 110(44%) patients were males and 140(56%) patients were females. It is observed that diabetes mellitus II is more common in patients of age groups (51-60) years. Pharmacotherapy revealed that 210 (81.6%) patients were treated with monotherapy followed by 34 (14%) patients with 2 drug therapy and 6 (4.4%) patients were prescribed with 3 drug therapy. Metformin was the drug of choice in monotherapy while metformin along with glimepiride was the preferred drug combination used in both 2 drug and 3 drug therapies. The overall drug usages in this study revealed that a total number of 301 drugs were prescribed. Out of which, metformin was most prescribed [128 (42.52%)]. CONCLUSION: Periodic evaluation of drug utilization patterns need to be done to provide suitable medications profile in prescription of drugs to increase the therapeutic benefit and reduce the adverse effects. The study of prescribing patterns require regular monitoring and evaluation and if necessary, suggestion of modification in prescribing pattern of medical practitioners to make medical care rational and cost effective. The current anti diabetic drugs includes insulin preparation and oral hypoglycemic agents (OHA), the preference is given mostly to metformin which is first choice of drug but the other drugs such as human insulin is also prescribed for many patients, also some combinations of (OHA) drugs are also preferred.

Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

IMPACT OF HYDROXYCHLOROQUINE IN COVID-19 AND ITS CLINICAL CONSEDERATIONS IN DRUG USAGE

Dr C.Nithish*, Dr.Vadla Vidyasagar
Departement of Clinical Pharmacy, Care Hospitals, Hyderabad, India.

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

BIO ANALYTICAL METHOD DEVELOPMENT AND VALIADTION FOR THE QUANITIFICATION OF CYTARABINE IN RAT PLASMA BY USING HPTLC

Supriya.Palaparthi*, Syed Afrin, M.Siva Prasad,Rama rao.N
Chalapathi Institute of Pharmaceutical Sciences, Guntur

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

STUDY OF ETHANOLIC EXTRACT ON DIFFERENT SPECIES OF PLUMERIA AS HERBAL INDICATOR.

Simran A. Pandey, Dr. Ujwala Dube, Mrs. Suchita Gokhale, Suraj Rajbhar
Ideal College of Pharmacy & Research.
(Affiliated to University of Mumbai, India).

Graphical Abstract

Abstract Article Highlights

The file does not exist in any folder.

Zenodo DOI Google Scholar

DOI Link

ASSESSMENT OF THE PRESCRIPTION PATTERN OF DRUGS USED IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HAEMODIALYSIS IN A TERTIARY CARE HOSPITAL

Anina Anil*, Jeni Joseph, Ria Maria Varghese, Stephy Chacko, Mr. B, Dr. Elessy Abraham
Nazareth College of Pharmacy, Othera, Thiruvalla.

Graphical Abstract

Abstract Article Highlights Download PDF (55) Zenodo DOI Google Scholar

DOI Link

SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF ISONIAZID AND PYRIDOXINE

Graphical Abstract

SIMULTANEOUS DETERMINATION OF METFORMIN AND GLIBENCLAMIDE IN PHARMACEUTICAL PREPARATION BY RP-HPLC

Graphical Abstract

A VALIDATED RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ARTESUNATE, SULFADOXINE AND PYRIMETHAMINE IN BULK AND TABLETS FORMULATION

Graphical Abstract

A STUDY OF PATTERN OF REFERRALS IN LIAISON PSYCHIATRY

Graphical Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF ORODISPERSIBLE TABLETS OF VALSARTAN USING SPRAY DRIED DILUENTS

Graphical Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF NOVEL ORODISPERSIBLE TABLETS OF OLMESARTAN

Graphical Abstract

A REVIEW ON NOVEL DRUG DELIVERY SYSTEMS ON LINCOSAMIDE ANTIBIOTICS-CLINDAMYCIN A MODEL DRUG

Graphical Abstract

PRE-FORMULATION STUDIES FOR FORMULATION AND DEVELOPMENT OF ETHOSOMAL GEL OF OXICONAZOLE NITRATE

Graphical Abstract

ASSESSMENT OF ADHERENCE TO INHALERS IN COPD PATIENTS

Graphical Abstract

DRUG UTILIZATION EVALUATION OF POST-OPERATIVE ANTIMICROBIALS USED IN SURGERY DEPARTMENT OF A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Graphical Abstract

GOLD NANOPRATICLES IN SCIENCE, TECHNOLOGY AND HEALTH CARE: A REVIEW

Graphical Abstract

ADVANCE TECHNIQUES IN TREATING CUTANEOUS FUNGAL INFECTIONS.

Graphical Abstract

REVIEW ON CELLULOSE DERIVATIVES

Graphical Abstract

PHARMACOGNOSTIC AND PHYTO-PHARMACOTHERPEUTIC PROFILE OF SPHAERANTHUS INDICUS: A POTENT INDIAN FOLK LORE MEDICINAL PLANT

Graphical Abstract

DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NEW 2-AMINO PYRIMIDINE DERIVATIVES

Graphical Abstract

RECENT ADVANCES IN MICROWAVE- ASSISTED SYNTHESIS

Graphical Abstract

PROSPECTIVE ASSESSMENT OF CHRONIC HEPATITIS B INFECTION AND CHRONIC HEPATITIS C INFECTION AS A RISK FACTOR IN ANTI-TUBERCULAR DRUGS INDUCED LIVER INJURY PATIENTS IN A TERTIARY HEALTH CARE HOSPITAL AT DEHRADUN, UTTARAKHAND (INDIA)

Graphical Abstract

KNOWLEDGE, ATTITUDE AND PRACTICE ASSESSMENT OF SOUTH SUDANESE REFUGEES IN ETHIOPIA TOWARDS TRADITIONAL MEDICINE: A CROSS SECTIONAL STUDY

Graphical Abstract

KNOWLEDGE, ATTITUDE AND PRACTICE ASSESSMENT OF DRUG DISPENSERS TOWARDS DRUG PRODUCTS STABILITY AT DRUG OUTLETS IN JIMMA TOWN: A CROSSECTIONAL STUDY

Graphical Abstract

SYNTHESIS AND CHARACTERIZATION OF ISOMERS OF COX-2 INHIBITOR, CELECOXIB

Graphical Abstract

DESIGN & MOLECULAR DOCKING STUDIES OF COUMARIN SUBSTITUTED 1, 3, 4-OXADIAZOLES AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS.

Graphical Abstract

DECOMPRESSIVE CRANIECTOMY WITH EVACUATION OF BLOOD IN HYPERTENSIVE BLOOD SURGICAL OUTCOME

Graphical Abstract

STUDY TO COMBAT ANTIBIOTIC RESISTANCE WITH STEWARDSHIP PROGRAM

Graphical Abstract

REVIEW ON: PHARMACEUTICAL DRUG REGULATORY AFFAIRS & REGULATORY REQUIREMENT FOR DRUGS APPROVAL IN INDIA, US & EUROPE MARKET

Graphical Abstract

NEUROPSYCHOLOGICAL STUDY ON ALZHEIMERS DISEASE : AN OVERVIEW OF PATHOGENESIS AND DIFFERENT TREATMENT APPROACHES

Graphical Abstract

DRUG UTILIZATION PATTERN OF ANTI DIABETIC DRUGS IN TYPE II DIABETIC PATIENTS IN A TEACHING AND GENERAL HOSPITAL

Graphical Abstract

IMPACT OF HYDROXYCHLOROQUINE IN COVID-19 AND ITS CLINICAL CONSEDERATIONS IN DRUG USAGE

Graphical Abstract

BIO ANALYTICAL METHOD DEVELOPMENT AND VALIADTION FOR THE QUANITIFICATION OF CYTARABINE IN RAT PLASMA BY USING HPTLC

Graphical Abstract

STUDY OF ETHANOLIC EXTRACT ON DIFFERENT SPECIES OF PLUMERIA  AS HERBAL INDICATOR.

Graphical Abstract

ASSESSMENT OF THE PRESCRIPTION PATTERN OF DRUGS USED IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HAEMODIALYSIS IN A TERTIARY CARE HOSPITAL

Graphical Abstract

DESIGN, SYNTHESIS AND CHARACTERIZATION OF SOME NEW 2-AMINO PYRIMIDINE DERIVATIVES

REVIEW ON: PHARMACEUTICAL DRUG REGULATORY AFFAIRS & REGULATORY REQUIREMENT FOR DRUGS APPROVAL IN INDIA, US & EUROPE MARKET

NEUROPSYCHOLOGICAL STUDY ON ALZHEIMERS DISEASE : AN OVERVIEW OF PATHOGENESIS AND DIFFERENT TREATMENT APPROACHES

STUDY OF ETHANOLIC EXTRACT ON DIFFERENT SPECIES OF PLUMERIA AS HERBAL INDICATOR.