IAJPR

Indo American Journal of Pharmaceutical Research

ISSN NO.: 2231-6876
JUNE 2024
1

A REVIEW ON IMMEDIATE RELEASE DRUG DELIVERY SYSTEM

M. Sowjanya*, S. Pavani Joginpally

B.R. Pharmacy College Yenkapally, Moinabad-500075, Hyderabad Telangana.

Tablets are the most popular of all dosage forms in existence because they are convenient, self-administered, compact and easy to prepare. However in many cases immediate treatment initiation is required compared to conventional treatments, immediate release tablet formulations are those using superdisintegrants such as croscarmellose, sodium starch glycolate, and crospovidone. These superdisintegrants cause tablets to disintegrate quickly after intragastric administration. Despite the remarkable advances in drug delivery, the oral route remains the most preferred route for the delivery of therapeutic agents due to low treatment costs and ease of administration, resulting in high level of patient compliance. Tablets is that do not require water and dissolve or disintegrant rapidly in saliva within seconds. Due to action of super solubilizers in the formulation or other new manufacturing technique. The demand of oral disintegrating tablets is high compared to other oral dosage forms{tablets, capsules, dry syrup chewing gums etc. Especially among elderly and paediatric patients travellers indigestion, patient and psychiatric patients. Patients considering the benefits of immediate release tablet and their growing demand. Various excipients are used in the preparation of tablet such as microcrystal, cellulose, lactose etc. Immediate release liquids and parenteral dosage forms are also used in treatment. These advances in the immediate release system also provide opportunities to increase the market and other types of drugs {such as neuroleptics cardiovascular drug analgesics antihistamine etc}. can be considered as competitors for this form of immediate release. These immediate release tablets and preparation technique, and dosage form evaluations.Tablets are the most popular of all dosage forms in existence because they are convenient, self-administered, compact and easy to prepare. However in many cases immediate treatment initiation is required compared to conventional treatments, immediate release tablet formulations are those using superdisintegrants such as croscarmellose, sodium starch glycolate, and crospovidone. These superdisintegrants cause tablets to disintegrate quickly after intragastric administration. Despite the remarkable advances in drug delivery, the oral route remains the most preferred route for the delivery of therapeutic agents due to low treatment costs and ease of administration, resulting in high level of patient compliance. Tablets is that do not require water and dissolve or disintegrant rapidly in saliva within seconds. Due to action of super solubilizers in the formulation or other new manufacturing technique. The demand of oral disintegrating tablets is high compared to other oral dosage forms{tablets, capsules, dry syrup chewing gums etc. Especially among elderly and paediatric patients travellers indigestion, patient and psychiatric patients. Patients considering the benefits of immediate release tablet and their growing demand. Various excipients are used in the preparation of tablet such as microcrystal, cellulose, lactose etc. Immediate release liquids and parenteral dosage forms are also used in treatment. These advances in the immediate release system also provide opportunities to increase the market and other types of drugs {such as neuroleptics cardiovascular drug analgesics antihistamine etc}. can be considered as competitors for this form of immediate release. These immediate release tablets and preparation technique, and dosage form evaluations.




2

SYNTHESIZE, CHARACTERIZATION AND EVALUATION OF ESTERIFICATION REACTION OF P-HYDROXY BENZOIC ACID, P-NITRO BENZOIC ACID AND DIFFERENT AMINO ACIDS WITH PARACETAMOL

Jilla Lavanya, Adere Sushma, Errolla Sneha, Methuku Venu, T. Rama Rao

CMR College of Pharmacy, Kandlakoya, Hyderabad-501401, Telangana.

Esterification is a fundamental chemical process with diverse applications across industries. This abstract explores the versatility and significance of esterification in various sectors, including food and beverage, pharmaceuticals, cosmetics, polymers, and renewable energy. By forming ester bonds between carboxylic acids and alcohols, esterification enables the synthesis of ester compounds, which serve as flavourings, fragrances, drug prodrugs, polymers, and biodiesel fuel. The process offers flexibility in molecular design, contributing to innovations in product development, sustainability, and consumer goods. Understanding the applications and importance of esterification provides insights into its role as a cornerstone of organic synthesis and industrial chemistry. 


 


3

ANXIETY AND DEPRESSION ASSOCIATED WITH SHEEHAN SYNDROME: A CASE REPORT

Karra Geetha1*, Udtha L Sahithya2, Chunchu Smaigdhini2 , Kotti Ramya sree2, T Rama Rao3

1Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya, Medchal.

2Department of Pharm D, CMR College of Pharmacy, Kandlakoya, Medchal.

3Department of Pharmaceutical Chemistry, CMR College of Pharmacy, Kandlakoya, Medchal.

Sheehan syndrome, a rare but serious postpartum condition, results from ischemic damage to the anterior pituitary gland caused by significant bleeding during or after childbirth. This damage leads to varying levels of pituitary hormone deficiencies, with symptoms ranging from lactation failure and amenorrhea to hypothyroidism and adrenal insufficiency, which can appear immediately after delivery or much later. Anxiety is increasingly noted as a significant comorbidity in Sheehan syndrome. The chronic hormonal deficits, especially of cortisol and thyroid hormones, are linked to neuropsychiatric symptoms, including anxiety. Secondary adrenal insufficiency leads to reduced cortisol levels, impairing the stress response and potentially heightening anxiety. Similarly, hypothyroidism affects mood and cognitive functions, further complicating mental health. Diagnosing Sheehan syndrome relies on clinical history, particularly obstetric hemorrhage, and pituitary hormone tests, with MRI scans often showing an empty sella or other pituitary abnormalities. Treatment involves lifelong hormone replacement tailored to specific deficiencies, including glucocorticoids, thyroid hormones, sex steroids, and sometimes growth hormone. Managing anxiety in these patients necessitates a multidisciplinary approach, incorporating psychological support, counseling, and potentially medications such as anxiolytics or antidepressants. Ensuring optimal hormone replacement is crucial, as it can help alleviate neuropsychiatric symptoms. In summary, Sheehan syndrome presents complex endocrine and psychiatric challenges. Early diagnosis and a comprehensive treatment plan addressing both hormonal and mental health aspects are essential for improving the quality of life for affected women. 


 


4

PHYTOTHERAPY IN DIABETES: A COMPREHENSIVE STUDY OF ANTIDIABETIC PLANTS

Avinash Bichave*, Rina Kadu, Shruti Khopkar, Tejaswi Bandgar, Shrutika Patil

TMV’s Lokmanya Tilak Institute of Pharmacy, Kharghar.

Diabetes mellitus (DM) is a metabolic disorder involving inappropriately elevated blood glucose levels. Various medicinal plants play a major role in the management of diabetes mellitus. These plants show various mechanisms of action, such as increased insulin sensitivity, decreased absorption of glucose, and altered activity of important metabolic pathways. Alkaloids, flavonoids, tannins, glycosides, polyphenols, steroids, and saponins are examples of bioactive substances that have been shown to have hypoglycemic effects. This study presents synergistic interactions between plant constituents and their safety profiles in the management of diabetes. It explores the mechanisms of action, phytochemical compounds, and clinical data that bolster their ability to prevent diabetes. This study offers new perspectives on the potential integration of medicinal plants into diabetes management strategies. The anti-diabetic properties of these plants are supported by clinical evidence, which emphasizes their potential as complementary or alternative therapies in the management of diabetes. These investigations provide valuable information to the expanding corpus of research on natural alternatives to treat diabetes, opening up new avenues for study and the creation of plant-based medical interventions.