Since a long time ago, one of the trendiest topics catching the attention of scientists is biosensing. This is true because biological systems are highly complex and are inextricably linked to the presence of a wholesome environment. Significant changes have also recently been made to the design of biosensors. Biosensors have gained popularity for a variety of uses, including the assessment of food quality, environmental monitoring, and the identification of clinical and metabolic issues. The field of nanotechnology has introduced several intriguing elements that have the potential to enhance sensing phenomena. Utilizing a variety of nanomaterials, including nanoparticles, nanotubes, nanorods, and nanowires, has greatly improved repeatability and allowed for speedier detection. The assembly of nanomaterial features is what gives rise to the special qualities of nanomaterials, which include strong electrical conductivity, improved shock resistance, sensitive reactions like piezoelectric and adaptable color-based detecting methods. This research focuses on the many kinds of biosensors that are based on various kinds of nanomaterials and discusses their implications and developmental features. 

Throwing up, retching, heaving, hurling, puking, tossing, or getting ill are all colloquial terms for vomiting, which is the forced voluntary or involuntary evacuation of stomach contents through the mouth or, less frequently, the nose. Vomiting is sometimes referred to scientifically as "emesis." There are various forms of regurgitation. One particular dopamine receptor (D2) blocker is domperidone maleate. Prolactin is released, gastrointestinal peristalsis is accelerated, and it is an antiemetic utilized in dopaminergic mechanism research. It functions as a peristaltic stimulant and a delayed adjuvant for gastric emptying. Domperidone maleate is a member of the dopamine receptor antagonist-prokinetic agent class of medications. It is a derivative of benzimidazole. Domperidone's ability to inhibit peripheral dopamine receptors is linked to its gastroprokinetic characteristics. Domperidone maleate reduces the pressure in the esophageal sphincter, increases gastric and esophageal peristalsis, and speeds up the process of emptying the stomach. Domperidone's ability to inhibit dopamine receptors both at the stomach level and in the chemoreceptor trigger zone is linked to its antiemetic effects. The D2 and D3 dopamine receptors, which are positioned in the chemoreceptor trigger zone, which is situated just outside the blood-brain barrier and governs a number of functions including nausea and vomiting, are highly affinitated by this substance. 

In modern era a major concern associated formulation development by using synthetic new chemical entitiesis theirpoor water solubility which poses problemsof low oral bioavailability. Lacidipine a antihypertensive drug, classified as BCA class II drug is one such example with low solubility and hence low oral bioavailability. In present work successfullyattempt has been made to carry out a comparative study of solubility and dissolution enhancements of Lacidipine using SLS as synthetic and saponine extracted from soya been as natural surfactants. At 1.5% of SLS and saponine solubility enhancement shown by Lacidipine in aqueous medium was 25.95 and 42.64mg/ml compared to 0.55mg/ml. Added advantage of saponine is it has lipid lowering capability. So a formulation developed using combination may show better management of hypertension.