“IMPACT OF INTRAVENOUS LIDOCAINE HYDROCHLORIDE INFUSION IN PERIOPERATIVE ANAESTHETIC CONSUMPTION AND POST-OPERATIVE ANALGESIA”
Lidocaine is a frequently used local anaesthetic, also having analgesic, antihyperalgesic and anti-inflammatory property. Lidocaine infusion provide intraoperative hemodynamic stability, less anaesthetic consumption and postoperative analgesia. Our aim was to compare relative doses of Lidocaine infusion to achieve adequate analgesia during intraoperative, postoperative period and also to notice consumption of sevoflurane. This is prospective, randomized double blind study included 150 patients of modified radical mastectomy, 50 patients in each group. Group A received 0.9% normal saline bolus and after that 0.9% normal saline infusion, Group B received Inj.Lidocain 2% 1.5mg/kg IV bolus and 1.5mg/kg/hr infusion and Group C received Inj.Lidocaine 2% 2mg/kg IV bolus and 2mg/kg/hr infusion intraoperative and infusion it was continued for 2 hour in postoperative period in each group. We had measured intraoperative pulse, blood pressure, sevoflurane consumption at every 15 minutes interval and postoperative pulse, blood pressure, VAS score, complication of infusion and sedation score every 30 minutes for 1st 2 hour, every 1 hourly for next 6 hours, every 2 hourly for next 2 hour. We had concluded that Group C has more intraoperative hemodynamic stability, less sevoflurane consumption (P<0.001) and late 1st analgesic requirement (480±168 minutes) (P<0.001).Sedation scale 1 was observed in 5 patients in group C, while none in Group A and Group B. There were no significant complications in any Group.